Hypersensitivity to the active substance, to other murine proteins, or to any of the excipients listed in section 6.1 of the Summary of Product Characteristics.

Patients with tuberculosis or other severe infections such as sepsis, abscesses, and opportunistic infections (see section 4.4 of the Summary of Product Characteristics).

Patients with moderate or severe heart failure (NYHA class III/IV) (see sections 4.4 and 4.8 of the Summary of Product Characteristics).